Polyoxyl 35 Castor Oil CAS 61791-12-6 Macrogolglycerol Ricinoleate EL-35 (EP/USP)

• Customization: Available
• CAS No.: 61791-12-6
• Formula: N/a
• Model NO.: SUREST-779
• EINECS: 500-151-7
• Packaging Material: Medical Aluminum Foil Bag
• Storage Method: Normal
• Shelf Life: 24 Months
• Type: Pharmaceutical Excipients
• Resource: Chemosynthesis
• Property: Non-ionic Emulsifiers
• Stock: Available
• Density: 1.05g/Mlat 20°c
• Boiling Point: 232.6ºC[at 101 325 PA]
• Flash Point: 257ºC
• Water Solubility: 24.11mg/L at 25ºC
• Specific Gravity: 1.05-1.06
• Viscosity (at 25°): 600-850 MPa·s
• Acid Value: ≤2 Ppm
• Saponification Value: 60-75
• Hydroxyl Value: 65-80
• Iodine Value: 25-35
• Transport Package: 20kg/Carton or 50kg/Barrel
• Specification: 99%min
• Trademark: Surest
• Origin: China
• HS Code: 3402420000
• Production Capacity: 1000 Tons Yearly

Product Description

Product Description

 

Name	Cremophor EL
Synonyms	Castor oil ethoxylated; Polyoxyethylene castor oil
CAS Registry Number	61791-12-6

 

Main Uses:

 

Properties:
- Appearance: The light yellow transparent oily substance, with a special smell.
- Solubility: It is miscible with water and can be dissolved with a variety of organic solvents.
- Stability: Polyoxyethylene castor oil is relatively stable at room temperature, but needs to avoid sunlight exposure.
 

Castor oil polyoxyethylene ether can be prepared by reacting castor oil with ethylene oxide under the catalysis of sodium hydroxide (or potassium). It is suitable for emulsification of various vegetable oils, mineral oils, fats,wax, etc. It can also be used as a component of antistatic spinning oil for synthetic fibers such as polyacrylonitrile, pesticide emulsifier, wool dredging agent and wool oil.

 

Pesticide emulsifier, textile chemical fiber oil agent, oil field crude oil dehydration.

The textile industry is used as chemical fiber oil agent, the wool spinning industry is used as wool oil, Vinylon anti-static spinning oil. It can also be used for emulsification of grease wax, oleic acid and mineral oil.
 

Biochemical research; Used for emulsifying and dissolving oils and other water-insoluble substances. Non-ionic solubilizer. As a solubilizer and emulsifier for water-insoluble drugs or other fat-soluble drugs, it is used in semi-solid and liquid preparations.
 

Application

Polyoxyethylene (35) castor oil (EL-35) EP/USP/CP

 

Pharmaceutical use of polyoxyethylene (35) castor oil (EL-35) as a pharmaceutical excipient:

1, Increasing solvent

a. Solubilization of fat soluble vitamins: Used for the solubilization of fat soluble vitamins such as vitamins A, D, E, K, etc., to form transparent or milky colored aqueous solutions and enhance their stability in aqueous formulations. It is necessary to pre mix with fat soluble ingredients and gradually add water to avoid local milky color.

b. Solubilization of hydrophobic drugs: Solubilizes hydrophobic drugs such as dichlorobenzimidazole, clotrimazole, and benzocaine to help them disperse uniformly in aqueous solutions. Adding auxiliary materials such as polyethylene glycol and propylene glycol can enhance the solubilization effect and reduce the amount of EL-35 used.

 

 

 

2, Emulsifier

Emulsification of liquid preparation: it is used for the preparation of fatty acids, fatty alcohols and drug lotion, and forms a stable lotion by adjusting the EL-35 ratio (5% -10%). As an emulsifier in injections, it ensures stable dispersion of fat soluble drugs such as paclitaxel.

 

 

 

3, Lubricants and Anti Adhesive Granules

Tablet lubrication: used as a substitute for magnesium stearate for easily sticky and washable tablets such as clopidogrel bisulfate tablets, with both lubrication and hydrophobic anti spotted effects, at a dosage of 0.2% -2%.

 

 

 

4, Application of special preparations

a. Injection carrier: As a solvent for chemotherapy drugs such as paclitaxel, it improves its water solubility and bioavailability.

b. Suppositories and cream bases: used for the preparation of glycerol suppositories to enhance drug release uniformity; As a component of cream base, it improves the permeability of hydrophobic drugs in skin preparations.

 

Specification

Tests	Specification
Appearance	Clear, yellow viscous liquid or semi-solid.
Identification	I. a. Infrared Spectroscopy b. A white precipitate is formed c. Fatty Acid Composition      Palmitic Acid: ≤4.0%      StearicAcid: ≤5.0%      Oleic Acid: 4.0%-10.0%      Linoleic Acid: ≤5.0%      Cis-11-Eicosenoic Acid: ≤1.0%      Ricinoleic Acid: 45.0%-75.0%
	II. a. Iodine Value (see Tests) b. Saponification Value (see Tests) c. Thin-layer Chromatography
Specific Gravity	1.05-1.06
Viscosity (at 25°)	600-850 mPa·s
Acid Value	NMT 2.0
Saponification Value	60-75
Hydroxyl Value	65-80
Iodine Value	25-35
Ethylene Oxide	NMT 1 μg/g
Dioxane	NMT 10 μg/g
Appearance of Solution	According to EP 10.0
Alkalinity	According to EP 10.0
Ethylene Glycol	NMT 620 ug/g
Sum of Diethylene Glycol and Ethylene Glycol	NMT 2500 μg/g
Water	NMT 3.0%
Residue on Ignition	NMT 3.0%

Peroxide Value	NMT 5
PH	5.0-7.0
Solubility	Freely soluble in water, very soluble in methylene chloride, freely soluble in ethanol (96 per cent).
Microbial Limits	Total Aerobic Microbial Count: NMT 100 cfu/g Total Combined Yeasts and Molds Count: NMT 100 cfu/g Escherichia Coli: absence P. aeruginosa: absence S. Aureus: absence Bile Tolerant Gram Negative Bacteria: absence Salmonella: Absence in 10g

 

Packaging & Shipping

 

• Packaging, Storage and Transportation: 20kg/carton;50kg/barrel.
  This series of products are non-toxic, non-flammable, according to the general chemical storage, and transportation, stored in a dry and ventilated place, a storage period of two years.

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Detailed Photos

 

 

FAQ

 

FAQ
Question 1: Can I get samples?
Answer: Yes,you can get free samples of our most products,
while the courier cost will be borne by the buyers.

Question 2: What's your MOQ?
Answer: For a express delivery order,the MOQ is usually 100 g~1 kg;
for an air transport order or sea delivery order ,the MOQ is usually 25 kgs.

Question 3: What's your delivery time?
Answer:
Orders shipped by express delivery,the delivery time is usually 5~7 working days;
Orders shipped by air transport,usually around 7~10 working days;
Orders shipped by sea , usually around 2~3 working weeks.

Question 4: What are the different payment methods?
Answer: We usually accept T/T, L/C and Western Union.

Question 5: How do you treat quality complaint?
We take quality very seriously, it is one of the founding principles of our business.
 If the quality problem actually exists, we will replace with qualified goods or refund the money.