Customization: | Available |
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CAS No.: | 31431-39--7 |
Formula: | C16h13n3o3 |
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Name | 5-Benzoyl-2-benzimidazolylcarbamic acid methyl ester; Methyl 5-benzoyl benzimidazole-2-carbamate |
Molecular Formula | C16H13N3O3 |
Molecular Weight | 295.30 |
CAS Registry Number | 31431-39--7 |
EINECS | 250-635-4 |
Melting point | 288.5 ºC |
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5-Benzoyl-2-benzimidazolylcarbamic acid methyl ester is a broad-spectrum deworming drug, which can completely kill the eggs of hookworm and whipworm and partially kill the eggs of roundworm.
5-Benzoyl-2-benzimidazolylcarbamic acid methyl ester has a strong affinity for the β-tubulin of worm and can bind to it at a very low concentration.
5-Benzoyl-2-benzimidazolylcarbamic acid methyl ester can inhibit the polymerization of its microtubules by affecting the metabolism of carbohydrate and related energy generation of worm, and cause the loss of the epidermal or intestinal cells of worm. It can selectively and irreversibly inhibit the uptake of glucose and other nutrients from the intestinal tract, and eventually lead to the death of the insect. It is suitable for the treatment of human and animal infections caused by whipworm, pinworm, hookworm, tapeworm, strongylodes faecalis, roundworm and other single or multiple worms, but it is not effective for echinococcosis.
5-Benzoyl-2-benzimidazolylcarbamic acid methyl ester is also an oxidative phosphoric acid uncoupling agent, which can inhibit fumarate reductase in mitochondria and reduce glucose transport, thus affecting ATP production.
5-Benzoyl-2-benzimidazolylcarbamic acid methyl ester suspension can inhibit the uptake of glucose by intestinal parasites, resulting in the depletion of glycogen stores and the reduction of adenosine triphosphate formation, but does not affect the glucose level in the blood of the host. Ultrastructural observation showed that the suspension of 5-Benzoyl-2-benzimidazolylcarbamic acid methyl ester could cause the degeneration of microtubules in the membrane cells and the cytoplasm of intestinal cells, resulting in the accumulation of secretory particles in Golgi, resulting in transport blockage, cytosolysis, complete degeneration of absorption cells, and death of the worm.
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