Customization: | Available |
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CAS No.: | 5266-20-6 |
Formula: | C5h3n2o4.Li |
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Name | Orotic acid lithium salt;Lithium orotate |
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Synonyms | 1,2,3,6-Tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid lithium salt |
Molecular Structure | |
Molecular Formula | C5H3N2O4.Li |
Molecular Weight | 162.03 |
CAS Registry Number | 5266-20-6 |
EC Number | 226-081-4 |
Lithium orotate is also known as vitamin B13. A white shiny acicular crystal or crystalline powder obtained from water, odorless and sour. Melting point 345 ~ 346ºC. Insoluble in cold water and ethanol, slightly soluble in hot water. It reacts with concentrated to form 5-chlorouracil-4-carboxylic acid. It can be obtained by condensation into diethyl butanoate, which is then hydrolyzed by urea.
Testing Items | Specifications | ||
Identification | HNMR confirms to structure | ||
Assay (based on dried) | 98.0%~102.0% | ||
Lithium ion | 3.5%~4.3% | ||
Appearance | Fine powder | ||
Color | White to off-white | ||
State of solution | Clear and colorless | ||
Odor | Characteristic | ||
Taste | Characteristic | ||
Partical Size | 60% pass 60 mesh | ||
Loss on Drying | ≤1.0% | ||
Heavy Metals | ≤20ppm | ||
Lead (Pb) | ≤0.5ppm | ||
Arsenic (As) | ≤1.5ppm | ||
Cadmium (Cd) | ≤0.5ppm | ||
Mercury (Hg) | ≤3.0ppm | ||
Chloride (Cl) | ≤0.1% | ||
Sulfate (SO4) | ≤0.1% | ||
pH | 5.5-7.5 | ||
Total Plate Count | ≤1000cfu/g | ||
Yeast | ≤50cfu/g | ||
Moulds | ≤50cfu/g | ||
E.Coli | Negative | ||
Salmonella | Negative |
The main uses of lithium orotate are as follows:
1, Mental disorder treatment
Bipolar disorder: As a mood stabilizer, it reduces the frequency and severity of manic episodes, and is safer compared to traditional lithium salts such as lithium carbonate.
Depression: Assisting in the improvement of depressive symptoms, especially for patients at risk of suicide, it has an emotional stabilizing effect.
Anxiety regulation: Relieve anxiety by increasing serotonin levels.
2, Neuroprotection and cognitive function
Neural repair: promotes the secretion of brain nerve growth factors and delays the progression of neurodegenerative diseases such as Alzheimer's disease.
Cognitive enhancement: improves attention, memory, and learning abilities.
Antioxidant and anti-inflammatory: reduce inflammatory factors and oxidative stress damage.
3, Anti tumor application
Targeted therapy for osteosarcoma:
Inhibiting tumor growth by phosphorylating GSK-3 β, combined with chemotherapy drugs such as doxorubicin, can enhance efficacy.
Used for preparing anti-tumor drug compositions containing lithium salts.
4, Nutritional supplementation and functional regulation
Dietary supplements:
Low dose is used to improve mild emotional fluctuations and anti-aging (under the guidance of a doctor).
Athletes use it to enhance cognitive function and stress resistance.
Regulating neurotransmitters: increasing dopamine and acetylcholine release, improving sleep and muscle function.
The core advantage of lithium orotate is its high efficiency in penetrating the blood-brain barrier, which can be effective at low doses and has lower side effects than traditional lithium salts.
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