Customization: | Available |
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CAS No.: | 1113-59-3 |
Formula: | C3h3bro3 |
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Name | Bromopyruvic acid |
Synonyms | 3-Bromopyruvic acid |
Molecular Structure | |
Molecular Formula | C3H3BrO3 |
Molecular Weight | 166.96 |
CAS Registry Number | 1113-59-3 |
EC Number | 214-206-5 |
Melting point | 56 ºC |
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Appearance: 3-bromopyruvic acid is a white or pale yellow powder.
Solubility: soluble in water and common organic solvents such as alcohols and ethers.
Main purpose:
1. Anti cancer research: As a potential anti-cancer drug, it targets rapidly proliferating tumor cells by inhibiting cancer cell energy metabolism (such as glycolysis).
2. Anti metabolism research: It is used to study the mechanism of metabolic diseases (such as diabetes and obesity), and explore treatment plans by interfering with abnormal metabolic pathways.
3. Antimicrobial applications: exhibiting inhibitory effects on certain drug-resistant bacteria or fungi, which may be used to develop new anti infective drugs.
4. Biochemical reagents: Used as tool compounds in the laboratory to study cellular energy metabolism pathways such as glycolysis and mitochondrial function.
Mechanism of Action
1. Inhibit glycolysis: Block the cancer cell dependent "Warburg effect" by targeting hexokinase II (HK-II) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH).
2. Inducing cell apoptosis: Activating apoptotic signals through the mitochondrial pathway (such as releasing cytochrome C) promotes programmed cell death in cancer cells.
3. Inhibition of ATP production: interferes with mitochondrial oxidative phosphorylation and glycolysis, leading to intracellular ATP depletion and inhibition of cell proliferation.
4. Antioxidant stress: Regulate levels of reactive oxygen species (ROS), disrupt the redox balance within cancer cells, and enhance chemotherapy sensitivity.
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