N-Oleoylethanolamine CAS 111-58-0 N- (2-Hydroxyethyl) Oleamide Oea

• CAS No.: 111-58-0
• Formula: C20h39no2
• EINECS: 203-884-8
• Certification: CCIC, CIQ, ISO
• Purity: 90%~99%
• Type: Sodium Hexametaphosphate
• Model NO.: SUREST-166
• Grade Standard: Industrial Grade
• Molecular Weight: 325.53
• Shelf Life: 2 Years
• Stock: Available
• Appearance: White
• Transport Package: 1kg/Bag or 25kg/Drum
• Specification: 98%min
• Trademark: Surest
• Origin: China
• HS Code: 2922110090
• Production Capacity: 1000 Tons Yearly

Product Description

N-Oleoylethanolamine
 

Name	N-Oleoylethanolamine
Synonyms	N-(2-Hydroxyethyl)oleamide; N-(cis-9-Octadecenoyl)ethanolamine; OEA
Molecular Structure
Molecular Formula	C20H39NO2
Molecular Weight	325.53
CAS Registry Number	111-58-0
EINECS	203-884-8

Chemical Property:
White powder.

Main Uses:
Oleoylethanolamine (OEA) is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-α) agonist. It is a naturally occurring ethanolamide lipid that regulates feeding and body weight in vertebrates ranging from mice to pythons.
OEA is the monounsaturated analogue of the endocannabinoid anandamide, but unlike anandamide it acts independently of the cannabinoid pathway, regulating PPAR-α activity to stimulate lipolysis.
OEA is produced by the small intestine following feeding in two steps. First an N-acyl transferase (NAT) activity joins the free amino terminus of phosphatidylethanolamine (PE) to the oleoyl group (one variety of acyl group) derived from sn-1-oleoyl-phosphatidylcholine, which contains the fatty acid oleic acid at the sn-1 position. This produces an N-acylphosphatidylethanolamine, which is then split (hydrolyzed) by N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) into phosphatidic acid and OEA. The biosynthesis of OEA and other bioactive lipid amides is modulated by bile acids.
OEA has been demonstrated to bind to the novel cannabinoid receptor GPR119. OEA has been suggested to be the receptor's endogenous ligand.
OEA has been reported to lengthen the life span of C. elegans through interactions with lysomal molecules.

 

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