Luteolin CAS 491-70-3 3′, 4′, 5, 7-Tetrahydroxyflavone 5, 7, 3′, 4′-Tetrahydroxyflavone

• CAS No.: 491-70-3
• Formula: C15h10o6
• EINECS: 207-741-0
• Certification: CCIC, CIQ, ISO
• Purity: 90%~99%
• Type: Sodium Hexametaphosphate
• Model NO.: SUREST-168
• Grade Standard: Industrial Grade
• Molecular Weight: 286.24
• Shelf Life: 2 Years
• Stock: Available
• Appearance: Yellow
• Melting Point: 330 ºC
• Transport Package: 1kg/Bag or 25kg/Drum
• Specification: 98%min
• Trademark: Surest
• Origin: China
• HS Code: 2932999099
• Production Capacity: 1000 Tons Yearly

Product Description

 Luteolin

Name	Luteolin
Synonyms	3',4',5,7-Tetrahydroxyflavone; 5,7,3',4'-Tetrahydroxyflavone
Molecular Structure
Molecular Formula	C15H10O6
Molecular Weight	286.24
CAS Registry Number	491-70-3
EINECS	207-741-0

Properties

Melting point	330 ºC

Chemical Property:
yellow  powder.

Main Uses:
1. Anti-inflammatory
activity of luteolin is thought to be related to other inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production, the inhibition of protein tyrosinine phosphorylation, and the gene expression mediated by nuclear transcription factor KB(NF-KB).

2. Anti-tumor
luteolin mainly inhibits tumor cell growth factors by changing cell signaling pathways or changes kinase activity to resist the infiltration of cancer cells, and can also inhibit tumor cell growth by blocking cell cycle and other ways. The results show that luteolin can selectively inhibit the activity of fatty acid synthetase in prostate and breast cancer cells, which is related to its anti-tumor cell growth and anti-apoptotic effect. Luteolin can significantly reduce the incidence and tumor size of colon cancer induced by dimethylhydrazine, which is related to the regulation of lipid peroxidation, anti-oxidation and anti-proliferation effects. Luteolin can inhibit the invasion of HO8910PM in vitro dose-dependent, which is related to inhibiting the secretion of matrix metalloproteinase-9 (MMP-9) and down-regulating the expression of extracellular signal-regulated kinase 2(ERK2).

3. Antiallergenic
luteolin can inhibit the release of immunoglobulin E(IgE) -mediated allergenic transmitters produced by human mast cells, including histamine, leukotrienes, prostaglandin D2, and mononuclear macrophage colony-stimulating factors, which may be related to the inhibition of Ca2+ influx and the activation of protein kinase C(PKC) translocation.

4. Mluteolin can protect oligodendrocytes against oxidative damage induced in vitro, strongly inhibit the phagocytic effect of macrophages on myelin sheath, significantly reduce the production of reactive oxygen species in cells, reduce the expression of iNOS protein, and significantly reduce the level of NO produced by macrophages at low doses.

5, anti-fibrotic
luteolin can reduce the degree of liver fibrosis, reduce the contents of hydroxyproline (HYP) and malondialdehyde (MDA) in liver tissue and the expression of type I procollagen mRNA, and inhibit the proliferation of hepatic stellate cells (HSC) and collagen synthesis in vitro. Moreover, it can improve the histopathological changes of pulmonary fibrosis caused ,reduce the lung mass index, significantly reduce the increase of MDA and HYP, and inhibit the expression of transforming growth factor-β1 (TGF-β1) mRNA in lung tissue, and inhibit the proliferation of human embryonic lung fibrocytes in vitro and promote their apoptosis.

6, lowering uric acid (anti-high uric acid) As a natural flavonoid, luteolin has the characteristics of inhibiting the activity of xanthine oxidase, thus inhibiting the production of uric acid. In addition, experiments have shown that luteolin has a significant role in promoting uric acid excretion when the dose is 100mg.kg-1.

7. Anti-fertility and hormone effects Luteolin has significant dose-dependent anti-implantation activity, which can significantly increase uterine weight, diameter, endometrial thickness and the height of its epithelial cells after oral administration. It has estrogen-like effects when applied alone, but shows anti-estrogen-like effects when combined with ethinylestradiol.

 

Detailed Photos