| Customization: | Available |
|---|---|
| CAS No.: | 98-59-9 |
| Formula: | C7h7clo2s |
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| Name | Tosyl chloride |
| Synonyms | 4-Toluene sulfochloride; 4-Methylbenzenesulfonyl chloride; p-Toluenesulfonyl chloride; Toluene-4-sulfonyl chloride; 4-Toluolsulfonyl chloride; p-Tosyl Chloride |
| Molecular Structure | |
| Molecular Formula | C7H7ClO2S |
| Molecular Weight | 190.64 |
| CAS Registry Number | 98-59-9 |
| EC Number | 202-684-8 |
| Melting point | 67-69 ºC |
|---|---|
| Boiling point | 134 ºC (10 mmHg) |
| Flash point | 128 ºC |
| Water solubility | hydrolyses |
Core uses of Tosyl chloride:
1. Organic synthesis field
Sulfonylation reaction:
Reacting with alcohols, phenols, and amines to form sulfonic acid esters (protecting hydroxyl groups) or sulfonamides (protecting amino groups), widely used in the preparation of organic intermediates;
Participate in the epoxidation reaction of 1,2-diol and the conversion of allyl alcohol to allyl chloride.
Selective modification:
Selective control of O - or N-sulfonylation can be achieved by adjusting solvents such as pyridine or triethylamine;
Promote Beckmann rearrangement reaction to generate lactam compounds.
2. Analytical Chemistry Applications
Derivative reagents:
Reacting with hydroxyl/amino compounds to generate easily detectable derivative products for GC-MS, HPLC-MS analysis of drugs, pesticides, and food ingredients;
Detecting drug impurities or preparing stable compounds (such as quality control reagents).
3. Pharmaceutical and Pesticide Industry
Drug synthesis:
Synthesis of sulfonamide drugs (such as metoclopramide), antibiotics, and anticancer drug intermediates;
Pesticide production:
Prepare herbicides (such as metoclopramide) and fungicides (such as metoclopramide).
4. Dyes and Fine Chemicals
Dye intermediates:
Introducing sulfonic acid groups for dispersing dyes, ice dyes, and acid dyes;
Molecular rearrangement reactions involved in hormone synthesis.
5. Polymer materials industry
Aggregation modification:
As an initiator or crosslinking agent for polymerization reactions, used for polymer functionalization modification;
The precursor for synthesizing sulfonated polymer materials.
6. Other industrial applications
Surfactants/Plasticizers: Synthetic industrial surfactants, plasticizers, and lubricants;
Preparation of fine chemicals: used for the synthesis of organic compounds such as ketones, esters, amides, etc.
P-Toluene sulfonyl chloride (PTSC) is a white crystalline powder. It has a minimum purity of 99% and a melting point not lower than 67ºC. The maximum water content is 0.05%, and the colority (APHA) should not exceed 20. The maximum content of free acid is 0.3%, and the maximum content of o-toluene sulfonyl chloride (OTSC) is 0.2%.
PTSC is an important organic compound with wide applications in the chemical and industrial fields. It is commonly used in the synthesis of pharmaceuticals, dyes, and high-molecular-weight materials. PTSC exhibits excellent chemical stability and reactivity, making it a valuable raw material for synthesizing intermediates and functional materials.
| Item | Unit | Specification |
| Appearance | - | White Crystalline Powder |
| Purity | % min | 99.5 |
| Melting Point | ºC min | 67 |
| Water | % max | 0.05 |
| Colority (APHA) | Pt/Co max | 20 |
| Free Acid | % max | 0.3 |
| OTSC(o-toluene sulfonyl chloride) | % max | 0.2 |
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