| Customization: | Available |
|---|---|
| CAS No.: | 22457-89-2 |
| Formula: | C19h23n4o6PS |
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| Name | Benfotiamine |
| Synonyms | N-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide-S-benzoate dihydrogen phosphate |
| Molecular Structure | |
| Molecular Formula | C19H23N4O6PS |
| Molecular Weight | 466.45 |
| CAS Registry Number | 22457-89-2 |
| EINECS | 245-013-4 |
Benfotiamine is a fat-soluble derivative of thiamine and has higher bioavailability than thiamine, but it must be dephosphorylated by alkaline phosphatase to become a fat-soluble precursor before it can cross the cell membrane to exert its biological effect. It is mainly used for the treatment of diabetic complications, especially for the treatment and prevention of diabetic retinopathy. Compared with other thiamine derivatives, this product is absorbed more quickly and completely after oral administration. Phenfothiamine is absorbed into the systemic circulation and is rapidly metabolized into thiamine without increasing the concentration of the drug in the brain, while hippuric acid is produced and excreted in the urine.
Benfotiamine (S-Benzoylthiamine O-monophosphate) is a fat-soluble analogue of vitamin B1, which has a higher absorption rate and bioavailability than vitamin B1, and is commonly used as a food supplement for complications of diabetes. Benfotiamine has direct antioxidant properties that prevent DNA damage.
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