Beta-Diphosphopyridine Nucleotide CAS 53-84-9 Beta-Dpn Beta-Nad

• CAS No.: 53-84-9
• Formula: C21h27n7o14p2
• EINECS: 200-184-4
• Certification: CCIC, CIQ, ISO
• Purity: 90%~99%
• Type: Sodium Hexametaphosphate
• Model NO.: SUREST-173
• Grade Standard: Food Grade
• Molecular Weight: 663.43
• Shelf Life: 2 Years
• Stock: Available
• Appearance: White
• Transport Package: 1kg/Bag or 25kg/Drum
• Specification: 98%min
• Trademark: Surest
• Origin: China
• HS Code: 2934999099
• Production Capacity: 1000 Tons Yearly

Product Description

beta-Diphosphopyridine nucleotide
 

Name	beta-Diphosphopyridine nucleotide
Synonyms	beta-Nicotinamide adenine dinucleotide; beta-DPN; beta-NAD
Molecular Structure
Molecular Formula	C21H27N7O14P2
Molecular Weight	663.43
CAS Registry Number	53-84-9
EINECS	200-184-4

Chemical Property:
White powder.

beta-Diphosphopyridine nucleotide also known as diphosphopyridine nucleotide (abbreviated DPN), or codehydrogenase I or Coenzyme I. In mammals, there are two states of oxidation (NAD+) and reduction (NADH). The oxidation (NAD+) has the maximum ultraviolet absorption spectrum at 260nm. By various deaminases, it accepts a hydrogen atom and an electron from the substrate and becomes a reduced (NADHChemicalbook). Maximum absorption occurs at 340nm. Beta-nicotinamide adenine dinucleotide is used as a coenzyme in REDOX reactions, as a donor of the ribose portion of ADP in the ribosylation of ADP, and as a precursor of the second messenger molecule cyclic ADP ribose. Beta-nicotinamide adenine dinucleotides also act as substrates for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins.




Main Uses:



beta-Diphosphopyridine nucleotide is involved in many physiological activities such as cell metabolism, energy synthesis, cell DNA repair, and plays an important role in the body's immune capacity.


In a healthy state, the concentration of beta-Diphosphopyridine nucleotide in the human body is stable, and the normal function of all cells is maintained. The concentration of beta-Diphosphopyridine nucleotide in the body determines the process and degree of cell aging, and the decrease of concentration will accelerate the process of cell aging. Studies have shown that NAD+ has a protective effect on renal infarction caused by ischemic surgery, and can significantly reduce the levels of serum urea nitrogen and creatinine. NAD+ has a protective effect on renal tubule injury caused by ischemic surgery. NAD + (nicotinamide adenine dinucleotide, NiChemicalbookcotinamideadeninedinucleotide, NAD +) can effectively protect the kidney ischemia caused by kidney damage, NAD + in the preparation of drug prevention and treatment of renal ischemic injury has important application value.


In addition, beta-Diphosphopyridine nucleotide has a certain application in the preparation of inflammatory pain drugs. NAD+ is involved in the regulation of inflammatory pain induced by formalin and complete Fredrin adjuvant (CFA) through NAD+ dependent deacetylases SIRT1 and SIRT2. SIRT1 and SIRT2 participate in the inhibitory effect of NAD+ on inflammatory pain through different mechanisms, so as to achieve analgesic effect on inflammatory pain.


1.beta-Diphosphopyridine nucleotide is a kind of coenzyme drug. Clinically, it is mainly used for the auxiliary treatment of coronary heart disease, which can improve chest tightness, angina pectoris and other symptoms. The side effects were dry mouth, dizziness, nausea and so on.

2.Participate in energy metabolism and material metabolism in the body, which is conducive to cell repair and renewal. It is used for the treatment of coronary heart disease, myocarditis, leukopenia and so on.





 

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