Customization: | Available |
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CAS No.: | 499-44-5 |
Formula: | C10h12o2 |
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Name | Hinokitiol |
Synonyms | 2-Hydroxy-4-isopropyl-cyclohepta-2,4,6-trien-1-one; 2-Hydroxy-4-(1-methylethyl)-2,4,6-cycloheptatrien-1-one; beta-Thujaplicin |
Molecular Structure | |
Molecular Formula | C10H12O2 |
Molecular Weight | 164.20 |
CAS Registry Number | 499-44-5 |
EINECS | 207-880-7 |
Melting point | 50-52 ºC |
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Boiling point | 140 ºC (10 mmHg) |
Preparation method
1 It was synthesized from methoxy cycloheptatriene by isopropylcycloheptatrienone and aminoisopropylcycloheptatrienone.
2. Hinokitiol was synthesized from carvone by six steps of epoxidation and acetalization.
3, From isopropyl cyclohexanone or isopropyl cyclohexenone is converted into hydroxyl nitrile, and isopropyl cycloheptanone is prepared in two steps, and then prepared by oxidation, bromination and debromination.
4. Bromocycloheptane chemicaltrienone reacts with an organic substance and is then synthesized by catalytic hydrogenation.
5. Isopropyl cyclopentadiene was prepared by addition of cyclopentadiene and one dichloroenone, and then solvenolysis was performed to synthesize hinokitiol through three-step reaction. The synthesis route of the first four preparation methods has too many steps or raw materials are difficult to obtain, and in fact can not be industrial production. Therefore, in recent years, the research on the fifth synthesis method is mainly concentrated.
Hinokitiol is a volatile oil component isolated from Japanese Cypress Cypress, which can reduce the expression of Nrf2, mRNA and protein expressions of DNMT1 and UHRF1, and has anti-infection, anti-oxidation and anti-tumor activities.
Hinokitol has many uses. It is widely used in the perfume and fragrance industry to add fragrance and fragrance to products. Secondly, hinokitiol is also used as a fungicide and preservative, often used in the preparation of disinfectants and fungicides.
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