Ethyl Bromopyruvate CAS 70-23-5 Ethyl 3-Bromopyruvate Bromopyruvic Acid Ethyl Ester

• Customization: Available
• CAS No.: 70-23-5
• Formula: C5h7bro3
• Model NO.: SUREST-759
• EINECS: 200-729-6
• Source: Organic Acids
• Appearance: Oily Liquid
• Grade Standard: Medicine Grade
• Colour: Light Yellow
• Shelf Life: 2 Years
• Stock: Available
• Molecular Weight: 195.01
• Density: 1.55
• Melting Point: 56 ºC
• Boiling Point: 98-100 ºC (10 Torr)
• Refractive Index: 1.4675-1.4765
• Flash Point: 98 ºC
• Water Solubility: Insoluble
• Transport Package: 25kg/Barrel
• Specification: 99%min
• Trademark: Surest
• Origin: China
• HS Code: 2918300090
• Production Capacity: 1000 Tons Yearly

Product Description

Product Description

 
 
 

Name	Ethyl bromopyruvate
Synonyms	Ethyl 3-bromopyruvate; Bromopyruvic acid ethyl ester
Molecular Structure
Molecular Formula	C5H7BrO3
Molecular Weight	195.01
CAS Registry Number	70-23-5
EC Number	200-729-6

Properties

Density	1.55
Boiling point	98-100 ºC (10 torr)
Refractive index	1.4675-1.4765
Flash point	98 ºC

 


 

Main Uses:

Ethyl bromopyruvate is a colorless liquid with a chili like odor. It is insoluble in water and soluble in organic solvents such as ethanol and ether. It is a strong C-Br activator that can be used as a bromination reagent in some organic reactions.

A. Main purpose
1. Anti tumor research
Targeted therapy: As a prodrug form of 3-bromopyruvic acid, ethylation enhances lipid solubility and improves cell membrane penetration ability, potentially used for targeted cancer metabolic therapy.
Combination therapy: Used in combination with chemotherapy or radiotherapy to enhance the sensitivity of traditional therapies by inhibiting glycolysis.

2. Antimicrobial applications
Broad spectrum antibacterial: It has inhibitory effects on drug-resistant bacteria (such as MRSA) and fungi (such as Candida), and may be used for the treatment of local infections.

3. Research on metabolic diseases
Intervention of diabetes model: explore the mechanism of improving insulin resistance by inhibiting abnormal glucose metabolism pathway.

4. Biochemical tool molecules
Metabolic pathway regulation: used for laboratory research on the molecular mechanisms of cellular energy metabolism and oxidative stress.

B, Mechanism of action
1. Conversion of prodrug
Under the action of cell lactonase, it hydrolyzes into the active form 3-bromopyruvate, directly inhibiting key glycolytic enzymes such as HK-II and GAPDH.

2. Metabolic interference
Blocking the Warburg effect in cancer cells reduces lactate production and inhibits mitochondrial ATP synthesis, leading to energy depletion.

3. Inducing apoptosis and autophagy
Activate mitochondrial apoptosis pathway (Caspase-3/9) and autophagy related protein (LC3-II) to promote tumor cell death.

4. Disruption of antioxidant balance
Raise intracellular ROS levels, disrupt redox homeostasis, and selectively kill high metabolic activity cells.





 

 

Detailed Photos

 

 

FAQ

 

FAQ
Question 1: Can I get samples?
Answer: Yes,you can get free samples of our most products,
while the courier cost will be borne by the buyers.

Question 2: What's your MOQ?
Answer: For a express delivery order,the MOQ is usually 100 g~1 kg;
for an air transport order or sea delivery order ,the MOQ is usually 25 kgs.

Question 3: What's your delivery time?
Answer:
Orders shipped by express delivery,the delivery time is usually 5~7 working days;
Orders shipped by air transport,usually around 7~10 working days;
Orders shipped by sea , usually around 2~3 working weeks.

Question 4: What are the different payment methods?
Answer: We usually accept T/T, L/C and Western Union.

Question 5: How do you treat quality complaint?
We take quality very seriously, it is one of the founding principles of our business.
 If the quality problem actually exists, we will replace with qualified goods or refund the money.