Customization: | Available |
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CAS No.: | 1571-30-8 |
Formula: | C10h6no3 |
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Name | 8-Hydroxy-2-Quinolinecarboxylicacid |
Molecular Structure | |
Molecular Formula | C10H6NO3 |
Molecular Weight | 188.16 |
CAS Registry Number | 1571-30-8 |
SMILES | C1=CC(=NC2=C(O)C=CC=C12)C([O-])=O |
InChI | 1S/C10H7NO3/c12-8-3-1-2-6-4-5-7(10(13)14)11-9(6)8/h1-5,12H,(H,13,14)/p-1 |
InChIKey | UHBIKXOBLZWFKM-UHFFFAOYSA-M |
Boiling point | 426.739°C at 760 mmHg (Cal.) |
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Flash point | 211.884°C (Cal.) |
Appearance:
8-hydroxyquinolin-2-carboxylic acid is usually yellow powder or yellow crystalline solid.
Solubility: It is soluble in water, but also soluble in some organic solvents, such as ethanol, acetone and chloroform.
The use of 8-hydroxy-2-quinolinecarboxylic acid:
1. Pharmaceutical research and treatment
IKK α inhibitor: As the core structure of BAY32-5915, this compound can inhibit IKK α enzyme activity (IC =60 nM) and has potential in the development of anti-inflammatory, anti-tumor and other drugs.
Antibacterial and anti infective properties: Its parent structure (8-hydroxyquinoline) disrupts bacterial metabolism by chelating metal ions, inhibiting the growth of drug-resistant bacteria. It is speculated that its carboxylic acid derivatives may expand similar antibacterial applications.
2. Chemical and Materials Industry
Organic synthesis intermediates: used for the synthesis of halogenated quinoline drugs, pesticides, and dyes, and are key raw materials in pharmaceutical and chemical production.
Polymer material modification: After being combined with polymer resins, new functional materials can be developed and applied in the fields of environmental protection, electroluminescence, and conductive polymers.
3. Metal ion analysis
Metal chelating agent: The parent compound 8-hydroxyquinoline is used as a metal ion extractant and analytical reagent, and it is speculated that its carboxylic acid derivatives may enhance the chelating ability for metal separation or detection.
4. Anti corrosion and mold prevention
Preservative derivatives: The parent compound is used as a preservative in cosmetics (limited to a concentration of 0.3%), and carboxylic acid derivatives may provide more stable preservative properties in similar scenarios.
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