| CAS No.: | 24512-63-8 |
|---|---|
| Formula: | C17h24o10 |
| EINECS: | N/a |
| Classification: | Monosaccharides |
| Appearance: | Liquid |
| Grade Standard: | Food Grade |
| Customization: |
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Audited Supplier | Name | Geniposide |
| Synonyms | Methyl (1R,2S,6S)-9-(hydroxymethyl)-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate |
| Molecular Structure | |
| Molecular Formula | C17H24O10 |
| Molecular Weight | 388.37 |
| CAS Registry Number | 24512-63-8 (27745-20-6) |
Geniposide has inhibitory effect on hemolytic streptococcus and skin fungi. It has antipyretic, analgesic, sedative, antihypertensive and hemostatic effects. Purging fire and eliminating boredom, clearing heat and dampness, cooling blood and detoxification, detumescence and pain relief. Symptoms include fever upset, manic disturbance, high fever irritability, dizziness and delirium, jaundice, red urine, heat and astringent pain, blood and heat epistaxis, eye red swelling pain, fire and poison sore; External treatment of contusion pain.
For content determination/identification/pharmacological experiments, etc. Pharmacological effect: Geniposide has the effects of laxative, analgesic, gallbladder, anti-inflammatory, treatment of soft tissue injury, inhibition of gastric secretion and decrease of pancreatic amylase.
An iridoid glycoside has a variety of biological activities, including neuroprotective, anti-diabetic, anti-proliferative, and antioxidant activities. Geniposide has been shown to regulate the translocation of Nrf2 and up-regulate the expression of downstream antioxidant protein HO-1 via the PI3K/Akt signaling pathway. Glucagon-like peptide-1 (GLP-1) receptor may also play a key role in gardeniin-induced HO-1 expression.
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